Fig. 5: Gelatin-fiber nonwoven fabric serves as a scaffold for migrating neurons.
From: Identification of the growth cone as a probe and driver of neuronal migration in the injured brain
a Dried and swollen gelatin fabrics. b, c The alignment distribution of gelatin fibers (b) and fiber centerlines (c). The color-code indicates the horizontal fiber orientation tensor (the more horizontal the fiber, the higher the value). d 3D image of voids among gelatin fibers in the fabric. The color-code indicates the void thickness. e Time-lapse images of migrating neurons (arrows) aligned with the control or Sdc2-containing gelatin fiber (pale pink) at different time points (minutes). f Representative Z-stack confocal images of migrating neurons (Dcx; red) on the gelatin fibers with or without Sdc2. g The speed of neurons migrating along the control or Sdc2-containing gelatin fibers embedded in Matrigel with CSPG. Scale bars: c, d, 100 µm; e, f, 5 µm. ***p < 0.005. Error bars indicate the mean ± SEM.
