Fig. 3: Novelty and phylogenomic distribution of the metagenome-assembled genomes and their biosynthetic potential.

a A phylogenetic tree built for all the TPMC genome-based species (n = 10,723) based on a concatenated alignment of 120 universally distributed bacterial single-copy genes and placement of each MAG in the GTDB-Tk reference tree. Two classes of the phylum Pseudomonadota are marked in the tree. The color of the branches indicates the phylum of the species. The outer layers indicate, for each species, the region and water ecosystem labels based on its MAGs, the count of MAGs, the largest count of BGCs among its MAGs, and the novelty (compared to the representative genomes of GTDB, GEM, and TG2G catalogs, respectively). b, c BGCs (n = 73,864) are clustered into GCFs (n = 18,414) and GCCs (n = 2681), with their novelty and the total number across different types presented. d MAGs with more than 20 BGCs are labeled in a, and the count of BGCs across different types of these MAGs is presented. MAG metagenome-assembled genome, BGC biosynthetic gene cluster, GCF gene cluster family, GCC gene cluster clan.