Fig. 7: Overlapping receptor sites for Neurotoxin Receptor Site II. | Nature Communications

Fig. 7: Overlapping receptor sites for Neurotoxin Receptor Site II.

From: Dual receptor-sites reveal the structural basis for hyperactivation of sodium channels by poison-dart toxin batrachotoxin

Fig. 7

a Superposition of BTX-B bound rNaV1.5c with bulleyaconitine (BLA)-bound hNaV1.3 (PDB: 7W77) (light gray) from the side view. Site IIB1, Site IIB2, and BLA are shown as sticks overlaid with transparent van der Waals spheres in bright green, cyan, and magenta, respectively. b Top view of Site IIB1, Site IIB2, and BLA. Site IIB2 (cyan sticks) and BLA (magenta sticks) have an overlapping binding pose. c Close-up view of the superposition as in (A) showing the receptor sites for Site IIB2 (cyan sticks) and BLA (magenta sticks). BTX-B and BLA compete for the same binding site near C899, G900 from DIII (lime green) and F1420 from DIII (yellow) in rNaV1.5c. Equivalent side chains in hNaV1.3 are shown as gray sticks.

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