Fig. 3: Genetic variation near exercise training genes is enriched in heritability across human phenotypes.

Here, we visualize conditional heritability enrichments (LDSC) of multiple traits within differentially expressed, sex-independent gene sets corresponding to different tissues. Colors distinguish tissues, with opaque diamonds corresponding to IHW-significant hits (α = 0.05), and size proportional to the magnitude of log₁₀(p-value) (two-sided, adjusted for multiple comparisons with IHW). The horizontal axis corresponds to the heritability enrichment factor, and the vertical to GWAS traits, grouped into high-level categories. Traits lacking an IHW-significant (α = 0.05) hit in at least one tissue are excluded from this visualization, and the horizontal axis has been truncated to exclude non-significant enrichments above that of the maximum significant enrichment, as well as estimated enrichments < 0, which are strictly impossible. Source data for this figure are provided as a Source Data file.