Fig. 4: Tropism of AAV viruses for different human tissues in humanized TIRFA mice.
From: A humanized mouse model for adeno-associated viral gene therapy
H&E staining of a teratoma from a TIRFA humanized mice (a) injected with AAV9-GFP virus (a, b, c) teratoma co-stained with GFP (green) and different markers (red) (c): Sox17, Snail, Cytokeratin 14 (K14), lactate dehydrogenase (LDH), cytokeratin 19 (K19), FAS receptor and Glutamine synthetase (GS). (d, e) Human tumor of a TIRF (d) and TIRFA (e) humanized mouse injected with AAV9-tdTomato stained with hLDH (magenta) and tdTomato (brown). H&E Hematoxylin and Eosin. GFP green fluorescent protein, RFP red fluorescent protein, hLDH human lactate dehydrogenase. Representative results were observed in at least 3 independent samples per condition. Scale bars represent 100 or 200 μm, respectively.
