Fig. 2: The FAS domain and the split core subunits.
From: Euglena’s atypical respiratory chain adapts to the discoidal cristae and flexible metabolism
Overall structure (a) and zoom-ins (b) of the FAS domain within Eg-SC I + III2 + IV. c Structural alignments of ND2 subunits between E. gracilis (this study, ND2A dark green, ND2B light green) and T. thermophila (PDB 7TGH, ND2A dark blue, ND2B light blue) are shown as super-imposed cartoons. d Structural alignments of ND2 subunits between Y. lipolytica (PDB 6RFR, light yellow) and O. aries (PDB 6ZKD, dark yellow) are also shown as a reference to (c). Structural comparison of T. thermophilus Nqo3 subunit (PDB 2FUG) (e) and E. gracilis NDUFS1 subunit (this study) (f). The NT and CT domains of T. thermophilus Nqo3 are colored by blue and different shades of green marking the four subdomains. E. gracilis NDUFS1A and NDUFS1B are colored in light blue and yellow respectively. g–i Association of the FAS domain onto Eg-CI PA. The NDUFS1A and NDUFS1B are shown in surfaces and other subunits are shown in cartoons. Relative rotations of the point of view between individual panels are labeled by their directions and degrees.
