Fig. 1: T-DOpE probe and CA1 electrophysiological activity in response to local chemical manipulations under natural and optically stimulated conditions.
From: T-DOpE probes reveal sensitivity of hippocampal oscillations to cannabinoids in behaving mice
T-DOpE probes offer higher complexities at the sensing tip while easing the connection between the backend and the electronics. The probe is implanted into behaving head-fixed mice expressing channel rhodopsin (ChR2) in pyramidal neurons in hippocampal area CA1. Local infusion of synthetic cannabinoid (CB1 Agonist, CP-55,940) in CA1 is sufficient to abolish both spontaneous and optogenetically induced sharp wave-ripples (SPW-R) (Scale bar: 5 mm).
