Fig. 3: T-DOpE probe connections and characterizations. | Nature Communications

Fig. 3: T-DOpE probe connections and characterizations.

From: T-DOpE probes reveal sensitivity of hippocampal oscillations to cannabinoids in behaving mice

Fig. 3

a Schematic of the T-DOpE probe backend connection process. b Photograph of a fully connected probe with eight electrodes, eight microfluidic channels, and four optical waveguides. (Scale bar: 5 mm) c Photograph of a straight probe and a probe bent roughly 45° to demonstrate the flexibility at the sensing end. d Impedance measurements of the BiSn electrodes before and after bending. All error bars and shaded colors represent the standard deviation. (Student’s two-tailed t-test, NS: not significant, p > 0.05 (After vs. Before, p = 0.3717, electrode numbers = 8)). Data are presented as mean ± SD. e Cross-sectional images to illustrate the individual addressability of the optical waveguides. (Scale bar: 50 µm) f Cartoon of green, blue, and orange food dye independently injected via the probe into a brain phantom. g Time-lapsed images to demonstrate the drug infusion in a 0.6% agarose gel. The inserted probe demonstrates the infusion of three different dyes at three different heights in the phantom. (Scale bar: 1 mm).

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