Table 1 a Comparison of models describing population dynamics of Marginal Zone B and Germinal Center B cell populations upon TD-immunization. b Parameter estimates from the best-fitting branched pathway with time-varying influx model

From: Notch2 controls developmental fate choices between germinal center and marginal zone B cells upon immunization

A

 

Model weights (%)

Time-varying influx

α,β = time-varying

δ, λ, μ = constant

Neutral

α,β, μ, δ, λ = constant

Time-varying loss

δ = time-varying

α,β, μ, λ = constant

Branched

79

0

0

Linear

7

0

0

Null

14

0

0

B

Parameter

Estimates

Median

95% Credible interval

Rate of influx of FoB into MZB (day−1)

1/1430

(1/5500, 1/770)

Time taken for the influx rate to halve (days)

14.2

(12.9, 15.4)

Rate of influx of CAR- to CAR+ MZB (day−1)

1/150

(1/270, 1/100)

Rate of net loss of MZB cells in Control/CAR (day−1)

0.49

(0.18, 0.87)

Rate of net loss of MZB cells in N2KO//CAR (day−1)

0.94

(0.55, 1.4)

  1. Relative statistical support for each model is indicated as % model weights (see Supplementary Note 1 for details on model weights estimation). Model-specific details are described in Fig. 8c–e. Here, α = rate of influx of Follicular B (FoB) cells into the Germinal Center B cell (GCB) compartment, β = rate of upregulation of CAR expression on Marginal Zone B (MZB) cells, μ = rate of differentiation of FoB into CAR+ MZB cells, δ = loss rate of CAR+ GCB cells, \(\lambda=\) loss rate of MZB cells. Best-fit model has the highest model weight (highlighted in blue bold font).
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