Fig. 6: Collagen cross-linking (SCXL) on rabbit sclera in vivo. | Nature Communications

Fig. 6: Collagen cross-linking (SCXL) on rabbit sclera in vivo.

From: A wireless battery-free eye modulation patch for high myopia therapy

Fig. 6

a Wireless ultrasonic energy system for photo-induced SCXL of the sclera. Riboflavin drugs appear as green particles in the visualization. b Optical images of the SCXL process. Right inset: The placement of the patch for implantation. Scale bar: 5 mm. c Tensile stress of rabbit eyes in the control and SCXL groups. d Young’s modulus of rabbit eyes in the control and SCXL groups. Statistical comparisons were performed using 95% confidence interval, two-sided, unpaired t test; *p = 0.0434, **p = 0.0059. n = 4 eyes per group. Data are presented as mean values ± SD. e H&E staining of the rabbit eye sections in both the control and SCXL groups. Scale bar: 100 μm. f Comparative analysis of tissue porosity, revealing slightly lower porosity in the SCXL group compared to the control group. Data are presented as mean values ± SD, using 95% confidence interval, two-sided, paired t test; *p = 0.0220. n = 3 eyes per group. Source data are provided as a Source Data file.

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