Fig. 2: Reaction condition optimization and substrate scope for β-mono-arylation.

a Model substrates selection. Reactions were run on a 0.2 mmol scale, yields are isolated yields. b Selected optimization for β-mono-arylation. Reactions were run on a 0.2 mmol scale, yields were determined by ¹H-NMR spectroscopic analysis using 1,1,2,2-tetrachloroethane (0.1 mmol) as the internal standard, isolated yields are given in parentheses, E/Z ratios were determined by ¹H-NMR spectroscopic analysis of the reaction crude. ^a18% 5b. ^b20% 3a”. c Substrate generality for β-mono-arylation. All data represent the average of (more than) two independent experiments, reactions were run on a 0.2 mmol scale, yields are isolated yields, E/Z ratios were determined by ¹H-NMR spectroscopic analysis of the reaction crude. ^cGram-scale reaction. ^d45 °C. ^eSingle-crystal structure of 3f, determined by X-ray diffraction. w/o, without.