Fig. 1: Mutational profile and prevalence of the XBB.1.5 SARS-CoV-2 lineage. | Nature Communications

Fig. 1: Mutational profile and prevalence of the XBB.1.5 SARS-CoV-2 lineage.

From: Altered receptor binding, antibody evasion and retention of T cell recognition by the SARS-CoV-2 XBB.1.5 spike protein

Fig. 1

A Amino acid mutations in the spike glycoprotein open reading frame for various Omicron and XBB sub-lineages. Each coloured box represents a mutation within a specific omicron sub-lineage. NTD amino terminal domain, RBD receptor binding domain. B Weekly weighted estimates of lineage proportion from sequencing data in the United States39. Weeks from 28 Jan–11 Feb 2023 represent Nowcast estimates which consistently align with the weighted proportions based on reported sequencing data. C CryoEM density map of the XBB.1.5 spike protein, with each protomer coloured a shade of blue or purple. D Resultant atomic model of the XBB.1.5 spike protein with modelled mutational locations denoted with red spheres on a single protomer.

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