Fig. 4: Identification of genes previously not known to play a role in the parathyroids.
From: Epigenetic profiling reveals key genes and cis-regulatory networks specific to human parathyroids
a Identification of previously unidentified genes that might have critical roles in the parathyroids by integrating expression, enhancer and GCM2-binding data. b GCM2 binding and chromatin states (top) for PAX1. Y-axis of GCM2 ChIP-seq: normalized read densities. The scale of the value is indicated in parentheses. The arrow indicates the transcription starting site and transcriptional direction. Chromatin states for the PAX1 locus in the parathyroid and other tissues from the Roadmap Epigenomics (middle). Expression levels in the parathyroid and other tissues from the GTEx project (bottom). Orange: parathyroid, Gray: other tissue types from the GTEx project. n = 8, biologically independent samples for parathyroids. The box represents the interquartile range (IQR) divided by the median, and Tukey whiskers extend to a maximum of 1.5 × IQR beyond the box. The colors in the box indicate chromatin states. c Same as in b but for PTHLH that is expressed in many tissue types. Broad and strong enhancers are restricted to the parathyroid. d Same as in b but for DNAH11.
