Fig. 2: Comparison of apo and bound IL-11. | Nature Communications

Fig. 2: Comparison of apo and bound IL-11.

From: Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency

Fig. 2

Structural model of the IL-11 receptor recognition complex (ribbon representation) overlaid on the cryoEM map (transparent surface) (a). Ribbon representations of gp130 P496L (blue), IL-11 (yellow), IL-11Rα (orange) are shown. The region encompassed by the dotted box is enlarged in the right panel. Arrow indicates residues T77-L90 of IL-11. b Superposition of IL-11 from the IL-11 receptor recognition complex (yellow) with the apo IL-11 structure (purple, PDB:6O4O); Residues T77-L90 are boxed. This region is shown in detail for the bound form of IL-11 (c) and apo IL-11 (d).

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