Fig. 3: Structural comparison of the IL-11 receptor recognition complex with the IL-6 cytokine complex. | Nature Communications

Fig. 3: Structural comparison of the IL-11 receptor recognition complex with the IL-6 cytokine complex.

From: Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency

Fig. 3

Interaction interfaces of IL-11 (left) or IL-6 (right) with gp130P496L (blue) at Site 2a (a), Site 2b (b), Site 3a (c) and Site 3b (d). IL-11 (yellow), IL-11Rα (orange), gp130P496L (blue), IL-6 (coral), IL-6Rα (green) are shown as ribbons with sidechains of interface residues shown as sticks. The IL-6 structural model shown is derived from the chimeric human cytokine IL-6 in complex with murine gp130P496L for a direct comparison with the IL-11 complex solved in this study.

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