Fig. 6: Behavioural specificity of hypothalamus connectivity predictions for stress.

A Out-of-sample predictions were achieved using nuclei-specific hypothalamus connectivity (all 105 edges as in Fig. 3C) for four alternative mental health dimensions: life satisfaction (LifeSat), negative emotions (NegEmot), Sleep and Anger (see ref. ⁵ for details). Significant predictions were achieved for Lifesat, NegEmot, and Anger, but not Sleep (one-sided correlations to assess positive relationships). B However, in all cases, prediction accuracies were lower than those achieved for stress, showing hypothalamus connectivity is particularly meaningful for stress. C Predictions achieved with increasing numbers of connections (as in Figs. 4A and 5C) show overall greater predictions for stress (turquoise line) compared to the four alternative dimensional scores when considering the peak and the smallest predictive network. D Correlations between dimensional control scores and stress scores show some shared variance, in particular for life satisfaction (negative) and negative emotions. Source data for 6B, C are provided as a Source Data file.