Fig. 1: Cartoon models of EGFR dimers. | Nature Communications

Fig. 1: Cartoon models of EGFR dimers.

From: Drug-resistant EGFR mutations promote lung cancer by stabilizing interfaces in ligand-free kinase-active EGFR oligomers

Fig. 1

a Left, Cartoon of a ligand-free tethered ectodomain (subdomains numbered) linked to a kinase monomer; the ATP-binding site, T766M mutation, and C-terminal tail are marked. Right, A two-liganded (EGF) extended back-to-back ectodomain dimer (B2Bectdimer) structurally coupled across the plasma membrane80 to an asymmetric kinase dimer (Asymkindimer)3, in which an “activator” kinase (teal) stabilizes a “receiver” kinase (dark green) in the active conformation. b Left, a ligand-free head-to-head ectodomain dimer (H2Hectdimer) sub-unit linked to two kinase monomers36. Middle, a ligand-free back-to-back ectodomain dimer (B2Bectdimer) sub-unit81 coupled to a head-to-head kinase dimer (H2Hkindimer) sub-unit35. Right, a ligand-free stalk-to-stalk ectodomain dimer (St2Stectdimer) sub-unit36 coupled to the Asymkindimer sub-unit36.

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