Fig. 3: Scope of tandem diyne cyclization/C(sp3)–H insertion of N-propargyl ynamides 1. | Nature Communications

Fig. 3: Scope of tandem diyne cyclization/C(sp3)–H insertion of N-propargyl ynamides 1.

From: Enantioselective functionalization of unactivated C(sp3)–H bonds through copper-catalyzed diyne cyclization by kinetic resolution

Fig. 3

1 (0.2 mmol), Cu(MeCN)4PF6 (0.02 mmol), NaBArF4 (0.024 mmol), L10 (0.024 mmol), mxylene (4 ml), 0 °C, 2–66 h, in Schlenk tubes; yields are those for the isolated products; ees are determined by HPLC analysis; drs are determined by crude 1H-NMR. a−20 °C.

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