Fig. 10: Schematic depiction of key findings.
From: Eph-ephrin signaling couples endothelial cell sorting and arterial specification
VEGF-A induces Esm1 expression in endothelial tip cells. High ephrin-B2 expression, which is linked to low EphB4, in tip cell progeny promotes arterial specification, which involves Notch activation, signaling by VEGFR2 and ERK1/2 together with the expression of the transcription factors SoxF and Dach1.
