Fig. 3: PEG MAP + BMP-2 treatment groups demonstrate increased matrix deposition at the defect site and morphological changes to the surrounding tissue.
From: Impact of PEG sensitization on the efficacy of PEG hydrogel-mediated tissue engineering
Images of H&E staining of calvarial defects of naive and sensitized top male and bottom female mice treated with PEG MAP + BMP-2 at 3 and 6 weeks post-implantation. Tissue samples from n = 4 mice per treatment group were analyzed. The entire calvaria was imaged to show the defect site (left side) and healthy, uninjured bone in the contralateral tissue (scale bar = 3 mm). Defect sites are indicated in solid-line boxes and magnified at ×4 (scale bar = 1 mm), and portions of the defect site that are magnified at ×10 are indicated in dashed-line boxes (scale bar = 200 μm).
