Fig. 6: Evaluation of in vivo therapeutic effect on rabbit ear HS under different interventions and reconstruction of pathological microenvironment. | Nature Communications

Fig. 6: Evaluation of in vivo therapeutic effect on rabbit ear HS under different interventions and reconstruction of pathological microenvironment.

From: Endogenous stimuli-responsive separating microneedles to inhibit hypertrophic scar through remodeling the pathological microenvironment

Fig. 6

a Diagram of the establishment of HS model and evaluation of the therapeutic effect. b Representative photographs of HS before and after different treatments. c SEI of different groups after the 3rd evaluation. d H&E staining of HS with different treatments before and after the 3rd evaluation. e Masson’s trichrome staining of HS with different treatments before and after the 3rd evaluation. f Fluorescence and immunofluorescence staining for DHE, 8-OHdG, MMP2 and MMP9 in NS and HS tissues with different treatments. The scale bar in the last images can be applied to the others in the same panel. Images in (b) and (d–f) are representative of n = 3 biologically independent samples. The data in (c) are presented as mean ± SD (n = 3 biologically independent samples). The data in (c) were analyzed using one-way ANOVA. P-value: n.s. means no significance, *P < 0.05.

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