Fig. 8: The function annotation of DEGs in full thickness rabbit ear HS model with drug-loaded MNs and 5-Fu injection treatment. | Nature Communications

Fig. 8: The function annotation of DEGs in full thickness rabbit ear HS model with drug-loaded MNs and 5-Fu injection treatment.

From: Endogenous stimuli-responsive separating microneedles to inhibit hypertrophic scar through remodeling the pathological microenvironment

Fig. 8

a Venn diagram showed the intersection of DEGs obtained by drug-loaded MNs compared with HS and 5-Fu injection compared with HS analysis. b GSEA results for up-regulated and down-regulated GO terms compared between drug-loaded MNs and HS groups. c GSEA results for up-regulated and down-regulated GO terms compared between 5-Fu injection and HS groups. d GSEA enrichment plot showing the top ranked down-regulated and up-regulated BioCarta pathways between drug-loaded MNs and HS groups. e GSEA enrichment plot showing the top ranked down-regulated and up-regulated BioCarta pathways between 5-Fu injection and HS groups. f The subnetwork of the 12 significant genes with higher degrees in the PPI network selected by MCODE. g Vertical bars of upper plot showing the intersection of the 20 hub genes screened by six algorithms in cytoHubba.

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