Fig. 6: Model for the evolutionary origin of Hoxc13 and hair keratin-dependent cornified skin appendages. | Nature Communications

Fig. 6: Model for the evolutionary origin of Hoxc13 and hair keratin-dependent cornified skin appendages.

From: Evolutionary origin of Hoxc13-dependent skin appendages in amphibians

Fig. 6

The evolutionary changes in the expression pattern of Hoxc13 and the appearance of the regulatory link between Hoxc13 and “hair keratins” were inferred from data obtained in extant vertebrates and their known phylogeny. “Hair keratins” refers to human keratins KRT31-KRT40 and KRT81-KRT86 and their orthologs in other species. Red and blue shading mark sites of expression of Hoxc13 and hair keratin homologs, respectively.

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