Fig. 3: Sequence conservation, lipid-filled central cavity, and water-filled lateral tunnel.
From: Substrate recognition mechanism of the endoplasmic reticulum-associated ubiquitin ligase Doa10
a Amino acid sequence conservation is mapped on the structure of Doa10. TMs 5 to 7 (referred to as the TD domain is indicated by dashed lines. The view (cytosolic view) is equivalent to that of Fig. 2a. b As in (a), but a lateral view from the central cavity to the middle domain. The lateral tunnel is highlighted in yellow. c A view into the entrance of the lateral tunnel. Shown in a lowpass-filtered cryo-EM map. The boundary of detergent features in the central cavity is indicated by a dotted line.
