Fig. 3: Parasite gene expression and parasitemia.
From: Gene expression analyses reveal differences in children’s response to malaria according to their age
The volcano plots show parasite gene expression associated with the parasitemia, unadjusted (A) and adjusted (B) for developmental stage composition using a quasi-likelihood negative binomial generalized model. Each point represents one gene, displayed according to its p-value (y-axis) and log fold-change (x-axis). Blue and red points represent genes that were significantly more expressed in low and high parasitemia infections, respectively, correcting for multiple testing using FDR (FDR = 0.1). Correlation of the proportion of rings (C) or trophozoites (D) (y-axis), estimated from gene expression deconvolution, with the log of the parasitemia (x-axis) using linear regression (respectively Pearson’s R2 = 0.13, p = 1.74 × 10−5 and Pearson’s R2 = 0.08, p = 0.0009). *DEG = differentially expressed gene. (N = 136 individuals).
