Table 2 Differential gene expression

From: Gene expression analyses reveal differences in children’s response to malaria according to their age

Variable

 

Human DEGsa

%age Human gene expression explained

P. falciparum DEGsa

%age P. falciparum gene expression explained

Parasitemia (parasites/µL)

Unadjusted (Adjustedb)

3221 (21)

3.36%

1779 (71)

5.24%

Participant’s age (years)

Unadjusted (Adjustedb)

4174 (1485)

4.52%

833 (6)

3.02%

No. subsequent symptomatic episodes

-

13

0.93%

6

0.73%

Time to next symptomatic malaria episode

-

0

0.87%

0

0.52%

Complexity of infection

-

0

0.23%

0

0.26%

Participant’s sex

-

68

0.33%

1

0.21%

  1. The table shows the number of human and P. falciparum genes associated with each clinical and epidemiologic variable (FDR = 0.1), before (unadjusted) and after (adjusted) adjusting for human immune cell or parasite developmental stage composition, respectively. All models included the host sex and month of infection as covariates, as well as age and parasitemia where appropriate. The mean proportion of overall variance in gene expression explained by each variable is also indicated for sake of comparison (see Fig. 1).
  2. aDEGs = differentially expressed genes (FDR = 0.1).
  3. bAdjusted for host immune cell or parasite developmental stage composition.
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