Fig. 1: Removal of miR-33 in AgRP neurons of adult mice promotes obesity and metabolic disfunction.
From: microRNA-33 controls hunger signaling in hypothalamic AgRP neurons
a–d Combined data on body weight (a and c), and fat and lean mass (b and d) from three independent cohorts of male (a, b) and female (c, d) wildtype (WT) and miR-33AgRPiKO mice fed a high fat diet (HFD). a (n = 12 WT and 14 miR-33AgRPiKO males); b (n = 11 WT and 13 miR-33AgRPiKO males); c (n = 12 WT and 11 miR-33AgRPiKO females); d (n = 12 WT and 10 miR-33AgRPiKO females). e, f Changes in blood glucose levels during a glucose tolerance test (left panels) and the calculated area under the curve (right panels) from three independent cohorts of male (e) and female (f) WT and miR-33AgRPiKO mice fed a HFD. e (n = 11 WT and 13 miR-33AgRPiKO males); f (n = 9 WT and 9 miR-33AgRPiKO females). g and i. Changes in blood glucose levels during an insulin tolerance test (left panels) and the calculated area under the curve (right panels) from one cohort of male (g) and two independent cohorts female (i) WT and miR-33AgRPiKO mice fed a HFD. g (n = 4 WT and 4 miR-33AgRPiKO males); i (n = 5 WT and 6 miR-33AgRPiKO females). h and j Plasma insulin levels in three independent cohorts of male (h) and female (j) WT and miR-33AgRPiKO mice fed a HFD. h (n = 7 WT and 9 miR-33AgRPiKO males); j (n = 10 WT and 12 miR-33AgRPiKO females). All data represent mean +/- SEM. Statistical Analysis assessed by unpaired 2-sided Student t-tests (b, d, e–j) or 2-way ANOVAs (a and c). Source data are provided as a Source Data file.
