Fig. 3: Mice lacking miR-33 in AgRP neurons have increased food consumption.
From: microRNA-33 controls hunger signaling in hypothalamic AgRP neurons
a, b Average daily food consumption in male (a) and female (b) wildtype (WT) and miR-33AgRPiKO mice fed a chow diet (CD) (n = 18 WT and 16 miR-33AgRPiKO males; n = 12 WT and 10 miR-33AgRPiKO females) or high fat diet (HFD) (n = 7 WT and 6 miR-33AgRPiKO males; n = 12 WT nd 9 miR-33AgRPiKO females). c, d Direct measurements of food consumption over time in chow diet fed individually housed male (c) and female (d) WT and miR-33AgRPiKO mice fasted for 24 h (n = 9 WT and 9 miR-33AgRPiKO males; n = 8 WT and 6 miR-33AgRPiKO females). e Direct measurements of food consumption over time in individually housed chow diet fed WT and miR-33AgRPiKO male mice treated with ghrelin (n = 9 WT and 9 miR-33AgRPiKO). All data represent mean +/- SEM. Statistical Analysis assessed by unpaired 2-sided Student t-tests (a–e). Source data are provided as a Source Data file.
