Fig. 4: Removal of miR-33 from AgRP neurons alters metabolic rate.
From: microRNA-33 controls hunger signaling in hypothalamic AgRP neurons
Metabolic cage analysis in a single cohort of male wildtype (WT) and miR-33AgRPiKO mice after 1 month of high fat diet (HFD) feeding. a–c Average measurements of oxygen (O2) consumption (a), carbon dioxide (CO2) production (b), and energy expenditure (c) across the full day or 12 h dark and light cycles in WT and miR-33AgRPiKO mice (n = 7). d–f Regression plots of average daily O2 consumption (d), CO2 production (e), and energy expenditure (f) as a function of body weight in WT and miR-33AgRPiKO mice (n = 7 WT and 7 miR-33AgRPiKO). Statistical analysis was performed using GLM ANCOVA (Supplementary Table 1). g, h Average measurements of respiratory exchange ratio (RER) (g) and activity (h) across the full day or 12 h dark and light cycles in WT and miR-33AgRPiKO mice (n = 7). All data represent mean +/- SEM. Statistical Analysis assessed by ANOVAs (a–c, g–h). Source data are provided as a Source Data file.
