Fig. 10: 19CAR-Tconvs worse the inflammatory lesions SGM-3 humanized mice. | Nature Communications

Fig. 10: 19CAR-Tconvs worse the inflammatory lesions SGM-3 humanized mice.

From: Regulatory T cells expressing CD19-targeted chimeric antigen receptor restore homeostasis in Systemic Lupus Erythematosus

Fig. 10

A Frequency and severity of the inflammatory lesions at the sacrifice in the different groups of early-administered treatment (3 weeks after pristane). N = 16 (5 early CAR-Tregs, 5 early CAR-Tconvs, 6 PBS). Two-tailed Chi-squared test. *p-value 0.041. B Livers of 3 different mice. Asterisk indicates an area of granulomatous inflammation. Reference bar 200 μm. C Ear pinnae of an early-treated CAR-Tconv mouse. Asterisk indicates an area of cutaneous Graft-versus-Host Disease. Reference bar 100 μm.

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