Fig. 4: Fox19CAR-Tregs immunomodulatory properties. | Nature Communications

Fig. 4: Fox19CAR-Tregs immunomodulatory properties.

From: Regulatory T cells expressing CD19-targeted chimeric antigen receptor restore homeostasis in Systemic Lupus Erythematosus

Fig. 4

Mean IL-10 (A), IFN-g (B) and IL-6 (C) levels in peripheral blood before and 3 days after the injection of Fox19CAR-Tregs, UT-Tregs or PBS. As control, humanized mice not treated with pristane (NT) are included. Cytokine levels were assessed employing a bead-based immunoassay (Biolegend Legendplex 13-plex kit) according to the manufacturer’s instructions. Each dot represents a single mouse. N = 34 (16 CAR-Tregs, 11 UT-Tregs, 7 PBS, 3 NT). Two-tailed Wilcoxon test for non-parametric paired data. *p-value < 0.025. D Frequency of human anti-dsDNA auto-antibodies in mouse serum in the different groups of treatment. N = 31 (15 CAR-Tregs, 11 UT-Tregs, 5 PBS). Two-sided Chi-squared test. *p-value 0.048.

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