Table 1 Genes within the 99th percentile of elevated FST and DXY genomic regions with a significant signature of selection according to the McDonald-Kreitman (MK) test

From: The global speciation continuum of the cyanobacterium Microcoleus

Gene ID (NCBI)

Gene abbreviations (prokka)

Gene name (prokka)

Localization (Number of genomes in which is present)

COG function

Neutrality Index (NI)

945060

dxs

1-deoxy-D-xylulose-5-phosphate synthase

Core genome (201)

Coenzyme transport and metabolism, Lipid transport and metabolism (COG1154)

*

945064

hepT

Heptaprenyl diphosphate synthase component 2

Core genome (201)

Isoprenoid biosynthesis; Coenzyme transport and metabolism (COG0142)

N < 1

33366736

srrA

Transcriptional regulatory protein

Core genome (201)

DNA-binding response regulator, NarL/FixJ family (COG2197)

N < 1

946396

cheR

Chemotaxis protein methyltransferase

Flexible genome (149)

Signal transduction mechanisms (COG1352)

*

946607

COQ3_4

O-methyltransferase

Flexible genome (49)

Ubiquinone biosynthesis; Coenzyme transport and metabolism (COG2227)

N > 1

948080

glyS

Glycine-tRNA ligase subunit β

Flexible genome (178)

Translation, ribosomal structure, and biogenesis (COG0751)

N < 1

945752

hcnC

Hydrogen cyanide synthase

Flexible genome (142)

Aminoacid transport and metabolism (COG0665)

N > 1

57664949

hemY

Protoporphyrinogen oxidase

Flexible genome (78)

Coenzyme transport and metabolism; Heme biosynthesis (COG1232)

N > 1

948805

ISAcma16

IS4 family transposase ISAcma16

Flexible genome

Mobilome: prophages, transposons (COG3385)

N < 1

\

ISWen2

IS110 family transposase ISWen2

Flexible genome

Mobilome: prophages, transposons (COG3547)

N < 1

946720

menD

2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase

Flexible genome (20)

Coenzyme transport and metabolism; Menaquinone biosynthesis (COG1165)

N < 1

945065

panE

2-dehydropantoate 2-reductase

Flexible genome (163)

Coenzyme transport and metabolism; Pantothenate and Coenzyme A synthesis (COG1893)

*

946712

pchA

Salicylate biosynthesis isochorismate synthase

Flexible genome (77)

Coenzyme transport and metabolism; Menaquinone biosynthesis (COG1169)

N > 1

\

phrB

(6-4) Photolyase

Flexible genome (95)

Uncharacterized protein related to deoxyribodipyrimidine photolyase (COG3046)

N > 1

852135

pknD_39

Serine/threonine-protein kinase PknD

Flexible genome (16)

Signal transduction mechanisms (COG0515)

*

946209

ppsA_1

Phosphoenolpyruvate synthase

Flexible genome (122)

Carbohydrate transport and metabolism; Gluconeogenesis (COG0574)

N > 1

946393

rcp1_3

Response regulator rcp1

Flexible genome (146)

Signal transduction mechanisms; Chemotaxis (COG0784)

N < 1

946611

rcsC_52

Sensor histidine kinase RcsC

Flexible genome (37)

Signal transduction mechanisms (COG0642)

N > 1

946611

rcsC_74

Sensor histidine kinase RcsC

Flexible genome (35)

Signal transduction mechanisms (COG0642)

N < 1

946611

rcsC_75

Sensor histidine kinase RcsC

Flexible genome (132)

Signal transduction mechanisms (COG0642)

N < 1

946611

rcsC_76

Sensor histidine kinase RcsC

Flexible genome (50)

Signal transduction mechanisms (COG2202)

N < 1

946611

rcsC_78

Sensor histidine kinase RcsC

Flexible genome (12)

Signal transduction mechanisms (COG0642)

N > 1

946611

rcsC_93

Sensor histidine kinase RcsC

Flexible genome (33)

Signal transduction mechanisms (COG0642)

N < 1

946611

sasA_33

Histidine kinase

Flexible genome (50)

Signal transduction mechanisms (COG2202)

N > 1

946611

sasA_43

Adaptive-response sensory-kinase SasA

Flexible genome (77)

Signal transduction mechanisms (COG0517)

N < 1

947913

sasA_44

Adaptive-response sensory-kinase SasA

Flexible genome (142)

Signal transduction mechanisms (COG0745)

N < 1

trmR_2

tRNA 5-hydroxyuridine methyltransferase

Flexible genome (182)

Translation, ribosomal structure, and biogenesis; tRNA modification (COG2520)

N > 1

944813

murF

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase

Flexible genome (100)

Cell wall/membrane biogenesis; Mureine biosynthesis (COG0770)

*

946915

hypothetical

Putative oxidoreductase

Flexible genome

Energy production and conversion (COG0243)

N < 1

  1. Given are their gene IDs (from the NCBI), abbreviations and names (from prokka annotations), localizations, a short functional description (COG), and a neutrality index (NI). The NI < 1 indicates positive selection and NI > 1 indicates negative selection. Loci under positive and negative selection between pairwise lineage comparisons are marked with an asterisk.