Fig. 6: Naked mole-rat heart is resistant to ischaemic damage. | Nature Communications

Fig. 6: Naked mole-rat heart is resistant to ischaemic damage.

From: Naked mole-rats have distinctive cardiometabolic and genetic adaptations to their underground low-oxygen lifestyles

Fig. 6

A Representative naked mole-rat and C57/BL6 mouse used in the study. B Langendorff heart ischaemia/reperfusion protocols, figure created with Biorender.com. C Images of representative cardiac sections from C57/BL6 mouse and NMR post I/R. Red colour- viable tissue, white areas- post-infarct scar. D Reduced infarct size in NMR vs C57BL6 post-myocardial ischaemia (20 min) and reperfusion (120 min) protocol **P = 0.0025. 1H nuclear magnetic resonance spectroscopy analysis of cardiac metabolites post-20-minute ischaemia in NMR vs C57/BL6 mouse, E elevated total adenine nucleotide pool (sum of ATP + ADP + AMP) *P = 0.039 two-tailed t test, F elevated myocardial glucose ***P = 0.0003 two-tailed, G elevated myocardial lactate **P = 0.0043 (H) reduced effluent lactate **P = 0.003 *P = 0.0439 two-tailed (I) reduced myocardial succinate ****P = 0.0001 and J reduced effluent succinate (1 min reperfusion) *P = 0.041. n = 5/group, Data mean ± SEM. t test two-tailed, data normality tested by Shapiro–Wilk. Source data are provided as a Source Data file.

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