Fig. 2: AXL and MERTK STRING networks similarly correlate with synovial histology. | Nature Communications

Fig. 2: AXL and MERTK STRING networks similarly correlate with synovial histology.

From: Axl and MerTK regulate synovial inflammation and are modulated by IL-6 inhibition in rheumatoid arthritis

Fig. 2

A, C Heatmaps showing regularised-log-transformed expression for all genes in the Axl module (A) and the MerTK module (C), (B, D) Axl module (B) and MerTK module (D) expression in synovial tissue of early arthritis treatment-naive RA patients (n = 81) according to the histological pathotype defined as Pauci-Immune (P-I, in green), Diffuse-Myeloid (D-M, in red), and Lympho-Myeloid (L-M, in blue). Data are represented as mean ±SEM. p values indicated were calculated using the Kruskal–Wallis test with Dunn’s post hoc test. E, F Enriched ontology pathways for the Axl module (E) and MerTK module (F). Nominal p values from gene set enrichment analysis are shown.

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