Fig. 3: Heterogeneity of P15 offspring hypothalamic neuronal subpopulations. | Nature Communications

Fig. 3: Heterogeneity of P15 offspring hypothalamic neuronal subpopulations.

From: Maternal dietary fat during lactation shapes single nucleus transcriptomic profile of postnatal offspring hypothalamus in a sexually dimorphic manner in mice

Fig. 3

a UMAP of canonical maker genes of glutamatergic, gamma-aminobutyric acid-ergic (GABAergic) as well as histaminergic (HA) neurons. b UMAP of neuronal subpopulations, colored by different neuronal subpopulations. c Dotplot shows the canonical marker genes for neuronal subpopulations. d GO enrichment analysis of cell type specific transcriptomic signatures shows significant enrichment (Padj < 0.05) in metabolic relevant categories of feeding behavior, insulin signaling, glucose homeostasis and circadian rhythm in several neuronal subpopulations. p value was adjusted by Benjamin-Hochberg correction. e Differential abundance analysis (DAseq) shows the enrichment of the abundance of cells from different neuronal subpopulations when comparing fHFD vs mHFD. Colored dots represent the enrichment of abundance in different groups.

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