Fig. 7: Conformational changes in the HTNV-L active sites between apo, 5′vRNA-bound intermediate, and 5′vRNA-bound active conformations. | Nature Communications

Fig. 7: Conformational changes in the HTNV-L active sites between apo, 5′vRNA-bound intermediate, and 5′vRNA-bound active conformations.

From: Structural characterization of the oligomerization of full-length Hantaan virus polymerase into symmetric dimers and hexamers

Fig. 7

Zoom on the active sites of monomeric apo HTNV-L on the top left, 5′vRNA-bound intermediate conformation in the top middle and 5′vRNA-bound active conformation on the top right. The motifs, the putative prime-and-realign loop (PR loop), the 5′vRNA-binding site are labeled and have specific colors. Superimposition of monomeric apo HTNV-L with 5′vRNA-bound intermediate conformation (bottom left) and superimposition of 5′vRNA-bound intermediate conformation with 5′vRNA-bound active conformation (bottom right) are shown to highlight motif movements.

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