Fig. 8: Model for the regulation of osteoclastogenesis by the Malat1-Tead3-Nfatc1 axis.
From: Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis
In the presence of Malat1 lncRNA, Malat1 sequesters Tead3, impeding its interaction with Nfatc1 and consequently constraining Nfatc1’s transcriptional activity. In the absence of Malat1, Tead3 is derepressed, facilitating its binding to Nfatc1 and promoting Nfatc1-mediated gene transcription. During RANKL-induced osteoclastogenesis from osteoclast progenitors (monocytes and macrophages), Malat1 is downregulated, and Tead3 is upregulated, thereby favoring osteoclast differentiation.
