Fig. 1: Tau-PET scans saved as a function of biomarker sensitivity.
From: A blood-based biomarker workflow for optimal tau-PET referral in memory clinic settings
A The top panel shows the percentage of tau-PET scans saved over the range of possible biomarker sensitivities for detecting tau-PET positive individuals for the BioFINDER-2 (left; n = 548) and TRIAD (right; n = 179) cohorts. Lines were estimated using a “loess” function over all bootstrapped trials. For example, a biomarker cutoff for pTau217 set at 90% sensitivity would result in a 50% reduction in tau-PET scans. B The lower panels show the percentage of tau-PET scans at specific biomarker sensitivity values (90, 95, and 97.5%) with confidence intervals and median derived from 100 bootstrap trials and represented by solid color bars. Source data are provided as a Source Data File. PET positron emission tomography, Aβ amyloid-beta, pTau phosphorylated tau, NfL neurofilament light, GFAP glial fibrillary acidic protein.
