Fig. 1: Replication kinetics of lab-adapted strains of PeV-A1 Harris, PeV-A3 152037, and E11 50473 in unguided neural organoids. | Nature Communications

Fig. 1: Replication kinetics of lab-adapted strains of PeV-A1 Harris, PeV-A3 152037, and E11 50473 in unguided neural organoids.

From: Parechovirus infection in human brain organoids: host innate inflammatory response and not neuro-infectivity correlates to neurologic disease

Fig. 1

a Schematic representation and timeline of the infection of UNOs, b relative increase in viral RNA copies in the supernatant at different time points, and c viral infectious particles from supernatant at 0, 5, and 10 dpi (days post-injection). In all cases, data correspond to the geometric mean ± geometric standard deviation (SD) of three technical replicates (individual organoids) for three batches (independent experiments) of organoids. Statistical significance was analyzed per virus using a Kruskal–Wallis test with multiple comparisons, *P value < 0.05; **P value < 0.01; ***P value < 0.001; ****P value < 0.0001. Source data are provided as a Source Data file. Biorender was used to generate (a).

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