Fig. 1: Manhattan plot of the genome-wide association studies meta-analysis for CAVS. | Nature Communications

Fig. 1: Manhattan plot of the genome-wide association studies meta-analysis for CAVS.

From: Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation

Fig. 1

The nearest gene at each genome-wide significant locus is indicated, in black for known loci and in red for novel loci. The association of each variant with calcific aortic valve stenosis was obtained from an inverse-variance weighted fixed-effect meta-analysis combining the effect per allele in the cohorts with available data. A p-value below 5 × 10−8 was considered significant (genome-wide threshold). The genomic inflation factor was 1.099 and the LD score regression intercept was 1.020. The quantile-quantile plot (inset) illustrates the distribution of p-values for each variant tested.

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