Fig. 3: Impact of homozygous risk genotype near TWIST1 on aortic valve gene expression. | Nature Communications

Fig. 3: Impact of homozygous risk genotype near TWIST1 on aortic valve gene expression.

From: Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation

Fig. 3

a Volcano plot representing the differentially expressed genes between individuals homozygous for rs7804522-C and individuals homozygous for rs7804522-G. Red points represent up-regulated genes (n = 148). Blue points represent down-regulated genes (n = 361). Statistical significance was set at P ≤ 0.001 corresponding to false-discovery rate <5% in the differential expression analysis. The top 10 up and down-regulated genes are labeled. b Lead independent enriched terms for the dysregulated genes. The statistical significance of the association for each term was obtained from a hypergeometric test and is illustrated by the color (p-value). The number of overlapping genes is illustrated by the size of the bubble.

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