Fig. 6: Individual risk profiles.

For example patients from (A) cluster 1, (B) cluster 2, (C) cluster 12 and (D) cluster 9. Waterfall plots show the top 15 most important features for estimating the OA risk at the individual level. Yellow bars (positive SHAP value) indicate features that increased predicted OA risk; red bars (negative SHAP value) indicate features that decreased predicted OA risk. Numbers within bars represent the SHAP value for the feature; numbers on the y-axis represent the value for this feature, both are specific to the individual shown and represented the magnitude of the effect of the risk biomarker on predicted OA risk. OA osteoarthritis, NSAIDs non-steroidal anti-inflammatory steroid drugs.