Fig. 1: Background for reaction development. | Nature Communications

Fig. 1: Background for reaction development.

From: Late-stage guanine C8–H alkylation of nucleosides, nucleotides, and oligonucleotides via photo-mediated Minisci reaction

Fig. 1

a Representative examples of bioactive C-8 alkylated nucleosides. b Selected examples of C8 alkylation of purine. c Selected examples of late-stage functionalization of purine of DNA/RNA. d Our strategy for late-stage functionalization of C-8 alkylated nucleosides, nucleotides, and RNA & DNA oligonucleotides. Me methyl, Et ethyl, tBu tert-butyl, Ac Acetyl, HMDS hexamethyldisilazane, CSA camphorsulfonic acid, DLP dilauroyl peroxide.

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