Fig. 3: Substrate scope of the nucleoside. | Nature Communications

Fig. 3: Substrate scope of the nucleoside.

From: Late-stage guanine C8–H alkylation of nucleosides, nucleotides, and oligonucleotides via photo-mediated Minisci reaction

Fig. 3

aGeneral condition: Guanosine (1.0 equiv.), alkylboronic acid (4.0 equiv.), MesAcr (5 mol%), (NH4)2S2O8 (2.0 equiv.), TFA (1.0 equiv.) and catechol (1.0 equiv.) in MeCN: H2O (1: 1, 0.1 M) on 0.2 mmol scale; irradiated by 85 W white light at R.T. for 16 h; isolated yield. bNo TFA was used. cRibose-cleaved byproduct 4 g’ was obtained in 71% yield. dUridine (1.0 equiv.), alkylboronic acid (4.0 equiv.), (NH4)2S2O8 (2.0 equiv.), MgCl2 (2.0 equiv.) and catechol (1.0 equiv.) in DMSO: H2O (1: 1, 0.1 M) on 0.2 mmol scale; irradiated by 36 W blue LED at RT for 24 h. HSV herpes simplex virus, HIV human immunodeficiency virus.

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