Table 4 Observational associations between triglycerides and cardiometabolic multimorbidity when pooling type 2 diabetes and ischemic heart disease together

From: Elevated blood remnant cholesterol and triglycerides are causally related to the risks of cardiometabolic multimorbidity

 

Serum triglycerides, mmol/L

 

<0.9

0.9–<1.3

1.3–<1.7

1.7–<2.3

≥ 2.3

P for trend

Disease free to T2D

      

  Cases/Total

582/63,480

1508/91,927

1863/71,493

2652/66,318

4986/72,359

 

  Incidence

7

13

22

33

59

 

  HR, 95% CI

1.00

1.33 (1.21, 1.47)

1.74 (1.59, 1.91)

2.26 (2.07, 2.48)

3.54 (3.24, 3.87)

<1 × 10−20

Disease free to IHD

      

  Cases/Total

1871/63,480

3852/91,927

3760/71,493

4141/66,318

5517/72,359

 

  Incidence

24

34

43

52

65

 

  HR, 95% CI

1.00

1.13 (1.07, 1.19)

1.23 (1.17, 1.30)

1.32 (1.25, 1.40)

1.51 (1.43, 1.59)

<1 × 10−20

T2D to IHD-T2D multimorbidity

      

  Cases/Total

27/546

102/1426

137/1777

198/2536

372/4760

 

  Incidence

110

147

158

157

146

 

  HR, 95% CI

1.00

1.21 (0.79, 1.85)

1.27 (0.84, 1.92)

1.24 (0.83, 1.86)

1.15 (0.77, 1.71)

0.500

IHD to IHD-T2D multimorbidity

      

  Cases/Total

25/1865

100/3845

142/3753

177/4123

378/5505

 

  Incidence

25

47

68

78

120

 

  HR, 95% CI

1.00

1.65 (1.07, 2.57)

2.05 (1.34, 3.14)

2.39 (1.57, 3.64)

3.39 (2.25, 5.11)

4.66 × 10−15

  1. Incidence was calculated as cases per 10,000 person-years. Hazard ratios were calculated via multistate modeling adjusting for age, sex, body mass index, systolic blood pressure, smoking status, pack-years of smoking, alcohol intake, physical activity, diet quality score, sleep quality score, and fasting time.
  2. CI confidence interval, HR hazard ratio, IHD ischemic heart disease, T2D type 2 diabetes.
  3. Statistical significance is set at two-sided P value < 0.05.
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