Fig. 4: Molecular interaction between BLV and NTCP.
From: Structure of antiviral drug bulevirtide bound to hepatitis B and D virus receptor protein NTCP
a Surface representation of NTCP (green), with the bound BLV peptide: myristoylated glycine (magenta), residues T3-G20 (orange), and residues P21-G48 (blue). b 2D schematic of the full BLV peptide, coloring is the same as in (a). c Sequence alignment of BLV and the preS1 peptides from the ten genotypes of HBV. Purple shading indicates amino acids conservation between BLV and different HBV preS1 genotypes. Black asterisks denote residues of BLV that are exposed to the solvent and therefore do not interact with NTCP. Red font indicates the HBV genotype used for the design of the BLV peptide. d–g Interactions between BLV and NTCP. Coloring as in panel (a). The EM density for BLV is displayed as blue mesh. BLV residues are labeled black.
