Fig. 5: Comparison of BLV-bound NTCP and substrate-bound NTCP.
From: Structure of antiviral drug bulevirtide bound to hepatitis B and D virus receptor protein NTCP
a, b Superposed BLV-bound NTCP (green) and substrate-bound NTCP (PDB ID: 7ZYI, gray) structures shown in ribbon representation. Two molecules of the substrate glycochenodeoxycholic acid (GCDC) are shown as gray sticks and the BLV peptide is colored as before. Close-up views show a clash between the substrate GCDC and TM6 of the BLV-bound NTCP structure (a), and a clash between GCDC substrates and the BLV peptide (b).
