Fig. 6: NTCP species specificity against HBV infection.
From: Structure of antiviral drug bulevirtide bound to hepatitis B and D virus receptor protein NTCP
a Sequence alignment between human NTCP and NTCP from two different species of monkeys: Cynomolgus monkey (Old World) and Common squirrel monkey (New World). Highlighted amino acids indicate the residues described in the text: the Gly/Arg variation at position 158, and Ser267 and its genetic variant Phe267, which has been linked to HBV resistance. b A close-up view of residue Gly158 (sphere representation) and its proximity to BLV (orange and blue transparent surface). c A close-up view of residue Ser267 (sphere representation) and its proximity to BLV (orange and blue transparent surface). d Topology diagram of human NTCP. Sodium binding sites (unoccupied in the NTCP-BLV structure) and substrate binding regions are indicated as empty circles and yellow diamonds, respectively. ECL extracellular loop, ICL intracellular loop. The crossing motif (X-motif) is formed by TM helices 3 and 8. Glycosylation sites are shown and numbered. Colored arches indicate the regions of NTCP interacting with distinct regions of the BLV peptide.
