Fig. 1: Repeated DSS injury induces social deficits in mice. | Nature Communications

Fig. 1: Repeated DSS injury induces social deficits in mice.

From: Colitis reduces active social engagement in mice and is ameliorated by supplementation with human microbiota members

Fig. 1

a Percent of original weight of 3–4-week-old male mice given DSS (gray) or control mice (black). Background shading illustrates treatment with DSS. (b) Area under the curve (AUC) of the data represented in (a), (P = <0.0001). At the end of behavioral testing, day 51, mice were weighed, and euthanized. Colon length (c) was assayed (P = 0.0017). a–c n = 40 animals/treatment analyzed over 4 independent experiments. At day 30 of schedule, mice were analyzed for behavioral changes. d Total movement in the open-field test (n = 15/treatment). e Proportion of total time spent actively socializing with an unfamiliar mouse (n = 15/treatment, P = 0.0286). Statistics: All bars/lines represent mean values +/− standard error of the mean (SEM). ns P > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001 for two-tailed unpaired Student’s T test (b–e).

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