Fig. 2: DSS-induced intestinal phenotypes are worsened by the microbiota of individuals with ASD. | Nature Communications

Fig. 2: DSS-induced intestinal phenotypes are worsened by the microbiota of individuals with ASD.

From: Colitis reduces active social engagement in mice and is ameliorated by supplementation with human microbiota members

Fig. 2

In all, 6–8-week-old male offspring of animals colonized with human microbiotas were subjected to DSS treatment for 7 days (n = 2–15 animals/microbiota). a Percent of original weight in NT-colonized (black) or ASD-colonized (gray) mice. b Area under the curve (AUC) of percent of original weight as shown in (a) (P = 0.0038). c Colon length at day 7 of DSS injury. d, h, l, p, t Pedigrees of five families included in the study. Gray shading represents ASD and white represents neurotypical controls. Circle indicates a female and square indicates a male. e, i, m, q, u Percent of original weight in NT-colonized (black) or ASD-colonized (gray) mice. f, j, n, r, v AUCs associated with the curves in (e, i, m, q, u). g, k, o, s, w Colon lengths at the end of DSS treatment time course. Statistics: *P < 0.05, **P < 0.01, ***P < 0.001 for two-tailed unpaired Student’s T test (b, n, o), and one-way ANOVA with Tukey’s multiple comparisons (j, k, s, v).

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